The aim of present work was to evaluate the effect of hydrophilic polymers and the effect of particle size on the release of Clozapine from matrix tablets. Hydrophilic polymerslike HPMC K 100 M, Guar gum and NaCMC were used as release retardant polymers and compressed the tablets using direct compression technology. The ratio of polymers used was 1:3, 1:4, 1:5 and 1:8. It was observed that the drug release decreased as the polymer ratio increased. The level of polymer ratio also had an effect on swelling index showing a linear relationship. At 1:8 (drug: polymer) ratio with HPMC K 100 M, tablets showed desirable release pattern, release up to 24 hr. It was found to release the drug in Zero order up to 24 hrs.For further study, 1:8 (drug: polymer) ratio was evaluated with particle sizes ranging from 250 micron to 106 microns on the release of drug. It was observed that as the particle size decreases, release also retards but follows zero order kinetics.
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